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Exertional Sickling occurs in athletes carrying the sickle cell trait. When the red blood cells change shape or “sickle” it causes a buildup of red blood cells in small blood vessels leading to decreased blood flow. This drop in blood flow leads to a breakdown of muscle tissue and cell death known as fulminant rhabdomyolysis.

Normal Red Blood Cells / Sickle Cell

Signs and Symptoms of Exertional Sickling:

  • Cramping Muscle Weakness > Muscle Pain

  • Fatigue

  • Slumps to Ground

  • Muscles Look and Feel Normal

  • Rapid Breathing

  • Core (Rectal) Temperature <102oF

What to do in the event of this emergency?

  • Check and monitor vitals.

  • Monitor for shock, responsiveness, tachycardia (fast heart rate) that begins to evolve into bradycardia (slow heart rate).

  • If available, give supplemental oxygen at 15 L/min by non-breather mask.

  • Cool athlete, if necessary.

  • Failing immediate improvement, call 911 and attach an AED. Be ready to start CPR, if needed.

  • Transport athlete.